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KMID : 1033720170180010009
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Archives of Craniofacial Surgery
2017 Volume.18 No. 1 p.9 ~ p.15
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Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
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Jung Bok-Ki
Lee Won-Jai
Kang Eun-Hye
Ahn Hyo-Min
Kim Yong-Oock
Rah Dong-Kyun
Yun Chae-Ok
Yun In-Sik
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Abstract
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Background: Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model.
Methods: Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared.
Results: Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group.
Conclusion: Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
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KEYWORD
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Gene Therapy , Cicatrix , Relaxin , Adenovirus
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